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KMID : 0613820110210030412
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Journal of Life Science
2011 Volume.21 No. 3 p.412 ~ p.416
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Polymorphisms of TAS1R3 and GNAT3 Genes Are Associated with Patients with Taste Disorder
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Bae Jae-Woong
Kim Un-Kyung
Kwon Tae-Jun
Choi Su-Jin
Ye Mi-Kyung
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Abstract
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Taste sensation plays a crucial role in selecting and ingesting foods with different qualities which convey information about their nutrient content and/or safety. Sweetness is one of the five modalities in humans and serves as an energy resource for metabolism. There are reports on allelic polymorphisms which influence perception of sweetness in mice and humans. Since the influence of genetic factors on taste disorder has not been studied, we investigated the association of genetic polymorphisms in TAS1R3 and guanine nucleotide binding protein, alpha transducing 3 (GNAT3) genes and taste disorder. A total of 150 individuals composed of 50 patients with taste disorder and 100 healthy controls were recruited for the study and PCR-mediated directing sequencing method was used to genotype for two different single nucleotide polymorphisms (SNPs) - rs307355 (T＞C) and rs35744813 (T＞C) in the TAS1R3gene, and rs7792845 (T＞C) and rs1524600 (C＞T) in the the GNAT3gene. The allele and genotype frequencies of rs307355 and rs35744813 in the TAS1R3gene showed a significant association between patients with taste disorder (p=0.022 and p=0.013 in both of SNPs, respectively). In addition, the frequency of T-T haplotype in the TAS1R3gene was higher in taste disorder cases than in the controls (OR, 1.93: 95%. CI, 1.09?3.39, p=0.022). In the GNAT3, the genotype frequency of rs7792845 in the patients was also different from the controls (p=0.048), but allele frequency was not significantly associated in either group. Our result provides the frequencies of SNPs and haplotypes of the TAS1R3 and GNAT3genes for the fundamental information of nutrigenetics in perception of the taste of sweetness in the Korean population. Also, the study suggests that the allelic polymorphisms of TAS1R3 and GNAT3genes may be useful as a molecular marker for evaluating patients with taste disorder. Further studies with large samples are required to clarify our observation.
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KEYWORD
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Sweet taste, taste disorder, gene, single nucleotide polymorphism, association
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